Reversed timing - dependent associative plasticity in 1 the human brain through interhemispheric 2 interactions
نویسندگان
چکیده
1 the human brain through interhemispheric 2 interactions 3 4 Short title: Ipsilateral paired associative stimulation 5 6 Virginia Conde, Henning Vollmann, Marco Taubert, Bernhard Sehm, 7 Leonardo G. Cohen, Arno Villringer and Patrick Ragert 8 9 Max Planck Institute for Human Cognitive and Brain Sciences, Department of 10 Neurology and Clinic for Cognitive Neurology University Hospital Leipzig, D11 04103 Leipzig, Germany 12 13 Mind Brain Institute, Charité and Humboldt University, D-10117 Berlin, 14 Germany 15 16 National Institutes of Health (NIH); National Institute of Neurological 17 Disorders and Stroke (NINDS), Human Cortical Physiology and Stroke 18 Neurorehabilitation Section, Bethesda, US 19 20 21 *Correspondence: 22 Patrick Ragert, PhD, Max Planck Institute for Human Cognitive and Brain 23 Sciences, Department of Neurology, Stephanstrasse 1a, 04103 Leipzig, 24 Germany 25 E-mail: [email protected] 26 27 28 Articles in PresS. J Neurophysiol (February 13, 2013). doi:10.1152/jn.01004.2012
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Reversed timing-dependent associative plasticity in the human brain through interhemispheric interactions.
Spike timing-dependent plasticity (STDP) has been proposed as one of the key mechanisms underlying learning and memory. Repetitive median nerve stimulation, followed by transcranial magnetic stimulation (TMS) of the contralateral primary motor cortex (M1), defined as paired-associative stimulation (PAS), has been used as an in vivo model of STDP in humans. PAS-induced excitability changes in M1...
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